Meet ATI, The New "Gluten". New Wheat Protein Found to Aggravate Chronic Health Issues, New Study!

Another wheat protein has been found that causes gastrointestinal problems and problems in other parts of the body like inflammation of the brain, lymph nodes, kidneys, spleen and other organs. It is called ATI or amylase trypsin inhibitor. ATIs make up no more that 4% of wheat proteins, but can trigger powerful immune reactions in the gut that can spread to other tissues in the body. The implications are massive.

Evidence suggests that ATIs can worsen the symptoms of rheumatoid arthritis, multiple sclerosis, asthma, lupus and non-alcoholic fatty liver disease, as well as inflammatory bowel disease.
That explains why some people eating wheat but don't have non celiac gluten sensitivity nor wheat allergy nor celiac are getting sick. 

This is another reason for the success of the GAPS or Paleo (without specific carbohydrates, legumes or chocolate) in resolving many health issues. 

More research has to be done to see if ATI is also found in other grains or cereals. According to Dr. Schuppan lead researcher of the study:

Wheat amylase-trypsin inhibitors (ATIs) have been identified as the most likely triggers of NCWS [Non Celiac Wheat Sensitivity]. They are highly protease resistant and activate the toll-like receptor 4 (TLR4) complex in monocytes, macrophages and dendritic cells of the intestinal mucosa. Non-gluten containing cereals or staples display no or little TLR4 stimulating activity. Wheat ATIs are a family of up to 17 similar proteins of molecular weights around 15 kD and represent 2-4% of the wheat protein. With oral ingestion they co-stimulate antigen presenting cells and promote T cell activation in celiac disease, but also in other immune-mediated diseases within and outside the GI tract.

Read the news report from WorldHealth.net  entitled -Wheat Protein Linked to Non-Celiac Gluten Sensitivity.  

Read the press release from United European Gastroenterology. from October 17th, 2016.



References:

1. Zevallos V, Weinmann-Menke J, Meineck M et al. Alpha-amylase/trypsin inhibitors (ATIs) accelerate murine systemic lupus erythematosus. Poster presentation at the 16th International Coeliac Disease Symposium, 21-24 June 2015, Prague, Czech Republic. Poster P168.

2. Zevallos V, Yogev N, Nikolaev A et al. Consumption of wheat alpha-amylase/trypsin inhibitors (ATIs) enhances experimental autoimmune encephalomyelitis in mice. Oral presentation at the 16th International Coeliac Disease Symposium, 21-24 June 2015, Prague, Czech Republic.

3. Junker Y, Zeissig S, Kim S-J et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 2012;209(13):2395-408.

4. Fasano A, Sapone A, Zevallos V et al. Nonceliac gluten and wheat sensitivity. Gastroenterology 2015;148(6):1195-204.

5.Schuppan D, Pickert G, Ashfaq-Khan M et al. Non-celiac wheat sensitivity: Differential diagnosis, triggers and implications. Best Pract Res Clin Gastroenterol 2015;29(3):469-76.
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