Celiac Caused By Other Proteins in Grains- GLO-3A

There has been vigorous scientific study of celiac disease and gluten sensitivity in the last few years. These studies continue to confirm that there may be as many of 400 different proteins, non-gluten, in grains that cause celiac disease and gluten sensitivity. And by extension, to heal, it confirms the use of a specific carbohydrate diet or Gut and Psychology Syndrome diet which is free of grains.

In a recent study published in the Journal of Pediatric Gastroenterology and Nutrition, the researchers studied a non-gluten storage protein in wheat, Glo-3A ( antibodies for Glo-3A are found in persons suffering from celiac disease).Thinking that these antibodies could be used to diagnose celiac disease, they found that they could infact diagnose celiac disease earlier than using the traditional serum TtG IgA.

Dr. Osborne at Glutenfreesociety, writes about the immune response to toxic grain proteins and about this study of Glo-3A in children at high risk of developing celiac disease:

Immune Response to Non Gluten Protein

The protein is called Glo-3A. It is a non gluten storage protein found in wheat.

Production of antibodies to Glo-3A is being studied as a marker to help in earlier diagnosis of gluten issues. In a study of children at high risk of developing the celiac disease, which attacks cells lining the small intestine, high levels of antibodies to Glo-3A were detectable in blood earlier than antibodies to tissue transglutaminase (TTG), a serologic marker frequently used to diagnose celiac disease.

“The present study shows that higher levels of Glo-3A antibodies are associated with celiac disease both at the time of clinical diagnosis and before that point,”

Glo-3A antibody production in the celiac group appeared, on average, about 2 years before TTG antibodies were detectable, at around age 3 versus age 5 for TTG antibodies.

The researchers in this study suspect that Glo-3A antibody production is a biomarker of impaired immune tolerance and increased gut permeability, i.e., celiac disease.
When diagnosing celiac disease, health care providers typically screen patients’ blood for the presence of TTG antibodies. TTG is an enzyme that alters the gliadin molecule by deamidating glutamine residues; these residues in turn bind to antigen presenting cells and activate T cells, leading to damage to the finger like cells called villi that line the small intestine. Over time, the cellular damage, known as villous atrophy, leads to malabsorption of food, gastrointestinal bloating, and diarrhea. But by the time TTG antibodies are detectable, villous atrophy has often already begun—prompting scientists to look for diagnostic tools that allow earlier diagnosis.

“These results may indicate that the immune pathology and subsequent damage that are characteristic of celiac disease start early in life”

You may have initially got better eating a traditional gluten free diet only to plateau or been told you have another autoimmune condition. Traditional gluten free diets that are not grain free, still expose you to toxic, non gluten, celiac promoting proteins. These proteins protect the grains from destruction by digestion, and to allow for wide distribution and propagation.
This study is one of many studies that have shown that grains contribute to disease processes.

In a future blog, I will describe the multiple toxic prolamines, also non-gluten proteins, found in grains.

I recommend a specific carbohydrate diet, updated by Dr. Campbell-McBride and called a GAPS diet.
For as long as it takes to clear up even the most minor problems, as these are signs of chronic inflammation, and chronic inflammation is the cause of most chronic illness of Western Societies including cancer.

All people are at risk of celiac disease. There is no constellation of symptoms or signs that is reliable for a clinical diagnosis. Get tested. If you don't have the money even for the genetic testing at www.enterolab.com  ,go on a GAPS diet and see how you do. Then as soon as possible get tested.

I don't know what to recommend if you don't have any gluten sensitivity or celiac genes. The evidence of the dangers to health of eating grains is enormous. But are there different "metabolic types" and some people can eat some small amounts of whole grains? I think so. But this is a subject for another day.

To your health

Dr. Barbara

Eat Good Fats and Get Healthy-Sally Fallon Video

Yes, eat good fats and get healthy. People with celiac disease or gluten sensitivity need even more good fats because of the common problem of not having enough cholesterol or triglycerides in the blood to support healthy cells and cell function. Read about cholesterol in a previous blog post.

But what is a good fat? What is a saturated fat, an unsaturated fat?

What is the difference between margarine and butter?

Is cholesterol something to be worried about?

Here is an excellent video of Sally Fallon, president of the Weston A. Price Pottinger Foundation, explaining the history of one change in our diets from a traditional diet. The video is called "The Oiling of America" and based on Dr. Enig's work in research in fats.

The DVD is 2 hours long. I hope you find the time to watch all of it. Enjoy. 

http://www.youtube.com/watch?v=fvKdYUCUca8

To your health.

Dr. B

Heal Your Gut To Make More Serotonin, and Feel Better

Yes, your bowel makes more serotonin than your brain does and some people call the bowel your second brain because it has more serotonin receptors too, than your brain. I have helped to resolve many peoples symptoms of anxiety, depression, learning disability, irritability and paranoia with focusing on healing the bowel, first. If you have been reading my blog, you know I mean the GAPS diet. The science that shows there is an association with improper growth of organisms (called dysbiosis) in the bowel and illness is very strong. There are many causes of dysbiosis: vitamin D deficiency, mother's use of birth control, birth by C/S, use of antibiotics without enough probiotics, stress, refined carbohydrates in the diet especially wheat, toxins in our food and drinking water, and foods that are devoid of healthy bacteria (diets without naturally fermented foods). So you see normal life in a western society can easily lead to dysbiosis.

And the consequences of the damaged bowel, and there are many: poor absorption of nutrients, mental health issues from mild to severe, autoimmune disorders, inflammation and more. A short list  and the remedies are listed here: http://articles.mercola.com/sites/articles/archive/2012/03/18/mcbride-and-barringer-interview.aspx

Here is a quote from the same article:

Your gut serves as your second brain, and even produces more serotonin—known to have a beneficial influence on your mood—than your brain does. It is also home to countless bacteria, both good and bad. These bacteria outnumber the cells in your body by at least 10 to one, and maintaining the ideal balance of good and bad bacteria forms the foundation for good health—physical, mental and emotional.
Most disease originates in your digestive system. This includes both physical and mental disease. Once you heal and seal your gut lining, and make your digestive system work properly again, disease symptoms will typically resolve
The GAPS protocol is designed to restore the integrity of your gut lining by providing your body with the necessary building blocks needed for health enterocyte reproduction, and restoring balance to your gut flora. Basic dietary details are included.

But the good news is that the bowel can be healed, in your own home, without toxic chemicals or expensive therapeutic medical expenses.

One of the super healing foods is Sauerkraut and here is one of my articles on Sauerkraut and a super easy recipe for it:

To your health,

Dr. B